Igor (2008)

John Cusack leads an all-star voice cast featuring Jay Leno, Molly Shannon, John Cleese, Jeremy Piven, Steve Buscemi, and Jennifer Coolidge in this computer-animated comedy about a gifted scientist who happens to have been born with a most unfortunate deformity. Igor (voice of Cusack) may have been born with a brilliant mind, but unfortunately everyone around him is too distracted by his pronounced hunchback to notice. Forced to serve as a lowly lab assistant to nefarious scientist Dr. Glickenstein (voice of Cleese), Igor longs for the day he will become a mad scientist, take top prize at the Evil Science Fair, and finally win the heart of village vixen Gretchen. Every year, mad scientists from all of the local villages converge on Malaria to compete in the annual Evil Science Fair -- an event that always features an abundance of death rays, earthquake generators, and man.